Dynamic Enzymatic Kinetic Resolution of Methyl 2, 3??Dihydro??1H??indene??1??carboxylate

J Pietruszka, RC Simon, F Kruska…

Index: Pietruszka, Joerg; Simon, Robert Christian; Kruska, Fabian; Braun, Manfred European Journal of Organic Chemistry, 2009 , # 35 p. 6217 - 6224

Full Text: HTML

Citation Number: 15

Abstract

Abstract A new reaction setup for kinetic enzymatic resolution was established and is demonstrated for the case of the hydrolase-catalysed conversion of methyl 2, 3-dihydro-1H- indene-1-carboxylate (1) in conjunction with a base-catalysed racemisation. The system allows controlled racemisation, resulting in efficient dynamic kinetic resolution (DKR) of the title compound. Short reaction times and high enantioselectivities were obtained with CAL ...

Related Articles:

Palladium complexes of bulky ortho-trifluoromethylphenyl-substituted phosphines: Unusually regioselective catalysts for the hydroxycarbonylation and …

[Grabulosa, Arnald; Frew, Jamie J.R.; Fuentes, Jose A.; Slawin, Alexandra M.Z.; Clarke, Matthew L. Journal of Molecular Catalysis A: Chemical, 2010 , vol. 330, # 1-2 p. 18 - 25]

A novel method for the synthesis of methyl indane-1-carboxylates by ring contraction of tetralones using lead (IV) acetate

[Nongrum, F.M.; Myrboh, B. Synthesis, 1987 , # 9 p. 845 - 846]

On the Conformation of the Substrate Binding to the Active Site during the Course of Enzymatic Decarboxylation.

[Bulletin of the Chemical Society of Japan, , vol. 69, # 12 p. 3591 - 3594]

A facile synthesis of phenylacetic acids from aryl ketones

[Belletire, J. L.; Howard, H.; Donahue, K. Synthetic Communications, 1982 , vol. 12, # 10 p. 763 - 770]

Microbial deracemization of α-substituted carboxylic acids: substrate specificity and mechanistic investigation

[Journal of Organic Chemistry, , vol. 68, # 19 p. 7234 - 7242]

More Articles...