Tubulin inhibitor 12

Modify Date: 2025-12-02 14:16:27

Tubulin inhibitor 12 structure	Common Name	Tubulin inhibitor 12
	CAS Number	92575-00-3	Molecular Weight	352.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tubulin inhibitor 12

Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC50=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity[1].

Name	Tubulin inhibitor 12

Description	Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC50=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Tubulin inhibitor 12 (0-100 μM; 72 h) shows moderate and broad-spectrum anti-proliferative activity[1]. Cell Proliferation Assay[1] Cell Line: HepG2, A549, and HCT116 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed IC50 values of 49.13, 52.84, and 70.10 μM for HepG2, A549, and HCT116 cells, respectively.
References	[1]. Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.

Molecular Formula	C₂₄H₂₀N₂O
Molecular Weight	352.43
InChIKey	BSYAMTMKRGNHEY-UHFFFAOYSA-N
SMILES	CN(Cc1ccccc1)C(=O)c1cc(-c2ccccc2)nc2ccccc12

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