Glycerol-d5

Modify Date: 2024-01-03 14:14:21

Glycerol-d5 Structure
Glycerol-d5 structure
Common Name Glycerol-d5
CAS Number 62502-71-0 Molecular Weight 97.12460
Density 1.331 g/mL at 25ºC Boiling Point 182ºC(lit.)
Molecular Formula C3H3D5O3 Melting Point 20ºC(lit.)
MSDS Chinese USA Flash Point 320 °F

 Use of Glycerol-d5


Glycerol-d5 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].

 Names

Name 1,1,2,3,3-pentadeuteriopropane-1,2,3-triol
Synonym More Synonyms

 Glycerol-d5 Biological Activity

Description Glycerol-d5 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.  

[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9.  

[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.  

 Chemical & Physical Properties

Density 1.331 g/mL at 25ºC
Boiling Point 182ºC(lit.)
Melting Point 20ºC(lit.)
Molecular Formula C3H3D5O3
Molecular Weight 97.12460
Flash Point 320 °F
Exact Mass 97.07870
PSA 60.69000
Index of Refraction n20/D 1.472(lit.)
Storage condition 2-8°C

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

~97%

Glycerol-d5 Structure

Glycerol-d5

CAS#:62502-71-0

Literature: Maegawa, Tomohiro; Fujiwara, Yuta; Inagaki, Yuya; Monguchi, Yasunari; Sajiki, Hironao Advanced Synthesis and Catalysis, 2008 , vol. 350, # 14-15 p. 2215 - 2218

~61%

Glycerol-d5 Structure

Glycerol-d5

CAS#:62502-71-0

Literature: Bersch, B.; Starck, J. P.; Milon, A.; Nakatani, Y.; Ourisson, G. Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 575 - 583

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 Synonyms

1,1,2,3,3-D5-glycerol
Bulbold-d5
Osmoglyn-d5
1,1,2,3,3-pentadeuterio-propane-1,2,3-triol
Glycerin-d5
MFCD00084148
Glyceritol-d5
Propanetriol-d5
Glysanin-d5
Glycerol-1,1,2,3,3-d5
glycerol-d5
Glycerine-d5