Piprofurol

Modify Date: 2025-08-25 13:09:53

Piprofurol structure	Common Name	Piprofurol
	CAS Number	40680-87-3	Molecular Weight	455.54300
	Density	1.214g/cm3	Boiling Point	640.7ºC at 760 mmHg
	Molecular Formula	C₂₆H₃₃NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	341.3ºC

Use of Piprofurol

Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].

Name	4-[3-[4,7-dimethoxy-6-(2-piperidin-1-ylethoxy)-1-benzofuran-5-yl]-3-hydroxypropyl]phenol
Synonym	More Synonyms

Description	Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	5 μM(guinea-pig papillary muscle)[1]
References	[1]. Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239.

Density	1.214g/cm3
Boiling Point	640.7ºC at 760 mmHg
Molecular Formula	C₂₆H₃₃NO₆
Molecular Weight	455.54300
Flash Point	341.3ºC
Exact Mass	455.23100
PSA	84.53000
LogP	4.62440
Index of Refraction	1.596
InChIKey	LIAPJIQUUKLLDZ-UHFFFAOYSA-N
SMILES	COc1c(C(O)CCc2ccc(O)cc2)c(OCCN2CCCCC2)c(OC)c2occc12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF6845120

CHEMICAL NAME :: 5-Benzofuranmethanol, 4,7-dimethoxy-alpha-(2-(4-hydroxyphenyl)ethyl)-6- (2-(1-piperidinyl)ethoxy)-

CAS REGISTRY NUMBER :: 40680-87-3

BEILSTEIN REFERENCE NO. :: 1276232

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C26-H33-N-O6

MOLECULAR WEIGHT :: 455.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 8,125,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,85,1974

EINECS 255-035-6

Piprofurol

Piprofurol [INN]

Piprofurolum

Piprofurolum [INN-Latin]

1-[4,7-dimethoxy-6-(2-piperidin-1-yl-ethoxy)-benzofuran-5-yl]-3-(4-hydroxy-phenyl)-propan-1-ol

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Piprofurol

Use of Piprofurol

Names

Piprofurol Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.