Clidanac

Modify Date: 2024-01-09 11:31:42

Clidanac structure	Common Name	Clidanac
	CAS Number	34148-01-1	Molecular Weight	278.77400
	Density	1.244g/cm3	Boiling Point	424.4ºC at 760mmHg
	Molecular Formula	C₁₆H₁₉ClO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	210.5ºC

Use of Clidanac

Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].

Name	Clidanac
Synonym	More Synonyms

Description	Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].
Related Catalog	Research Areas >> Infection
In Vitro	Clidanac can uncouple the oxidative phosphorylation and no difference in the uncoupling potency of the two enantiomorphs[1].

Density	1.244g/cm3
Boiling Point	424.4ºC at 760mmHg
Molecular Formula	C₁₆H₁₉ClO₂
Molecular Weight	278.77400
Flash Point	210.5ºC
Exact Mass	278.10700
PSA	37.30000
LogP	4.50210
Index of Refraction	1.587

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK4503000

CHEMICAL NAME :: 1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-

CAS REGISTRY NUMBER :: 34148-01-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H19-Cl-O2

MOLECULAR WEIGHT :: 278.80

WISWESSER LINE NOTATION :: L56T&J BVQ HG G- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,1297,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 88400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 825 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982

HS Code	2916399090

5-Cyclohexyl-1-...

CAS#:38240-91-4

Clidanac

CAS#:34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

2-(4-cyclohexyl...

CAS#:34177-35-0

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

4-cyclohexylben...

CAS#:27634-89-5

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

α-Cyan-4-cycloh...

CAS#:38913-05-2

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

6-chloro-5-cycl...

CAS#:31861-70-8

Clidanac

CAS#:34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

(3-chloro-4-cyc...

CAS#:31962-03-5

Clidanac

CAS#:34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

5-Cyclohexyl-1-...

CAS#:52487-42-0

Clidanac

CAS#:34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

Precursor 6
CAS#:38240-91-4 5-Cyclohexyl-1-... CAS#:34177-35-0 2-(4-cyclohexyl... CAS#:27634-89-5 4-cyclohexylben... CAS#:38913-05-2 α-Cyan-4-cycloh...
CAS#:31861-70-8 6-chloro-5-cycl... CAS#:52487-42-0 5-Cyclohexyl-1-...
DownStream 0

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

(+-)-6-Chlor-5-cyclohexyl-1-indancarbonsaeure

1H-Indene-1-carboxylic acid,6-chloro-5-cyclohexyl-2,3-dihydro-(9ci)

6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid

6-Chloro-5-cyclohexyl-1-indancarboxylic acid

Britai

6-chloro-5-cyclohexylindan-1-carboxylic acid

Indanal

(+-)-6-Chlor-5-cyclohexylindan-1-carbonsaeure

Clidanac

Use of Clidanac

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Clidanac Biological Activity

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Precursor & DownStream

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