Mpro/PLpro-IN-1

Modify Date: 2025-08-27 17:34:22

Mpro/PLpro-IN-1 Structure
Mpro/PLpro-IN-1 structure
Common Name Mpro/PLpro-IN-1
CAS Number 2766185-78-6 Molecular Weight 466.96
Density N/A Boiling Point N/A
Molecular Formula C25H27ClN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mpro/PLpro-IN-1


Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM)[1].

 Names

Name Mpro/PLpro-IN-1

 Mpro/PLpro-IN-1 Biological Activity

Description Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of Mpro/PLpro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus Mpro (IC50 = 1.72 μM) and submicromolar potency versus PLpro (IC50 = 0.67 μM)[1].
Related Catalog
References

[1]. Di Sarno V, et al. Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. Eur J Med Chem. 2021;226:113863.

 Chemical & Physical Properties

Molecular Formula C25H27ClN4O3
Molecular Weight 466.96
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