5α-Pregnane-3β,6α-diol-20-one

Modify Date: 2024-01-04 12:34:02

5α-Pregnane-3β,6α-diol-20-one structure	Common Name	5α-Pregnane-3β,6α-diol-20-one
	CAS Number	21853-11-2	Molecular Weight	334.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5α-Pregnane-3β,6α-diol-20-one

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

Name	5α-Pregnane-3β,6α-diol-20-one

Description	5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Steroids
In Vitro	Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].
References	[1]. Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. [2]. de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191.

Molecular Formula	C₂₁H₃₄O₃
Molecular Weight	334.49
Storage condition	2-8℃