PAT-1251 Hydrochloride
Modify Date: 2024-01-03 09:14:04
PAT-1251 Hydrochloride structure
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Common Name | PAT-1251 Hydrochloride | ||
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| CAS Number | 2098884-53-6 | Molecular Weight | 435.8 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18ClF4N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAT-1251 HydrochloridePAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). |
| Name | PAT-1251 Hydrochloride |
|---|
| Description | PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). |
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| Related Catalog | |
| Target |
IC50: 0.10 μM (Mouse LOXL2), 0.12 μM (Rat LOXL2), 0.16 μM (Dog LOXL2), 0.71 μM (hLOXL2), 1.17 μM (hLOXL3)[1] |
| In Vitro | PAT-1251 is a lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with <10% inhibition at 10 μM[1]. |
| References |
| Molecular Formula | C18H18ClF4N3O3 |
|---|---|
| Molecular Weight | 435.8 |
| Storage condition | 2-8℃ |