RWJ 63556

Modify Date: 2024-01-07 08:40:13

RWJ 63556 structure	Common Name	RWJ 63556
	CAS Number	190967-35-2	Molecular Weight	287.330
	Density	1.5±0.1 g/cm3	Boiling Point	403.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₀FNO₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	197.8±31.5 °C

Use of RWJ 63556

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

Name	RWJ 63556
Synonym	More Synonyms

Description	RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	COX-2 5-Lipoxygenase
In Vitro	RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].
In Vivo	RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].
References	[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.

Density	1.5±0.1 g/cm3
Boiling Point	403.4±55.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₀FNO₃S₂
Molecular Weight	287.330
Flash Point	197.8±31.5 °C
Exact Mass	287.008606
LogP	4.22
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.624
Storage condition	2-8℃

Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]-

N-[5-(4-Fluorophenoxy)-2-thienyl]methanesulfonamide