AZD 4407

Modify Date: 2024-01-06 10:57:16

Use of AZD 4407

AZD 4407 is a potent 5-lipoxygenase inhibitor.

Name	5-[4-[(2S,4R)-4-hydroxy-2-methyloxan-4-yl]thiophen-2-yl]sulfanyl-1-methyl-3H-indol-2-one
Synonym	More Synonyms

Description	AZD 4407 is a potent 5-lipoxygenase inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	5-lipoxygenase[1]
In Vitro	In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407)[1].
References	[1]. Jonathan Hutton, et al. Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407. Org Process Res Dev. 1997 Jan 15;1(1): 61–67.

ZD 4407

2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]

2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-(tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl)-2-thienyl]thio]-,(2S-trans)

AZD 4407