c-Fms-IN-6

Modify Date: 2024-01-06 23:32:18

c-Fms-IN-6 structure	Common Name	c-Fms-IN-6
	CAS Number	1628574-81-1	Molecular Weight	419.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₅N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of c-Fms-IN-6

c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].

Name	c-Fms-IN-6

Description	c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
Target	IC50: ≤10 nM (c-FMS)[1]
In Vitro	c-Fms-IN-6 (Example 38) shows inhibitory activity against M-NFS-60 cell proliferation, with an IC50 in the range of 0.01 μM to 0.1 μM[1].
References	[1]. Gary E. L. BRANDT, et al. 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145023A1.

Molecular Formula	C₂₂H₂₅N₇O₂
Molecular Weight	419.48