tert-Butyl pent-4-yn-1-ylcarbamate

Modify Date: 2024-01-11 11:15:14

tert-Butyl pent-4-yn-1-ylcarbamate Structure
tert-Butyl pent-4-yn-1-ylcarbamate structure
Common Name tert-Butyl pent-4-yn-1-ylcarbamate
CAS Number 151978-50-6 Molecular Weight 183.24700
Density N/A Boiling Point N/A
Molecular Formula C10H17NO2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS05
GHS05
Signal Word Danger

 Use of tert-Butyl pent-4-yn-1-ylcarbamate


N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1].

 Names

Name N-Boc-4-pentyne-1-amine
Synonym More Synonyms

 tert-Butyl pent-4-yn-1-ylcarbamate Biological Activity

Description N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1].
Related Catalog
Target

Alkyl-Chain

References

[1]. Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.

 Chemical & Physical Properties

Molecular Formula C10H17NO2
Molecular Weight 183.24700
Exact Mass 183.12600
PSA 41.82000
LogP 2.12890

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Hazard Codes C
RIDADR UN 2735PSN1 8 / PGII
HS Code 2924199090

 Synthetic Route

~42%

tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: WO2013/96771 A1, ; Page/Page column 215 ;

~85%

tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: Synthesis, , # 9 art. no. Z17611SS, p. 1477 - 1483

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tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: Organic Letters, , vol. 9, # 15 p. 2887 - 2889

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tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: US2011/152321 A1, ;

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tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: WO2013/96771 A1, ;

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tert-Butyl pent-4-yn-1-ylcarbamate Structure

tert-Butyl pent...

CAS#:151978-50-6

Literature: WO2013/96771 A1, ;

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

tert-butyl N-pent-4-ynylcarbamate
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