Cefilavancin

Modify Date: 2024-01-11 15:55:56

Cefilavancin structure	Common Name	Cefilavancin
	CAS Number	1393900-12-3	Molecular Weight	1983.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₇H₉₅Cl₃N₁₆O₂₈S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cefilavancin

Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimer antibiotic with effective activity against Gram-positive bacteria. Cefilavancin has been used to research skin infections[1][2][3].

Name	Cefilavancin

Description	Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimer antibiotic with effective activity against Gram-positive bacteria. Cefilavancin has been used to research skin infections[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Glycopeptide
In Vitro	Cefilavancin (TD-1792) has highly active against Methicillin-susceptible Staphylococcus aureus (MIC90 = 15 ng/mL), Methicillin-resistant Staphylococcus aureus, and heterogeneous Vancomycin-intermediate Staphylococcus aureus (MIC90 = 30 ng/mL)[1].
In Vivo	Cefilavancin (0.03-10 mg/kg; s.c.) produces a dose-dependent reduction of thigh bacterial burden in infected mice[3]. Animal Model: Female NSA mice (18-30 g; neutropenia induced by administering cyclophosphamide, then injected bacteria into the posterior thigh)[3] Dosage: 0.03-10 mg/kg Administration: s.c.; single dosage (every 24 h) or two (every 12 h), three (every 8 h), or four (every 6 h) divided doses Result: Produced a maximal of approximately 1- to 2-log10 kill against MRSA ATCC 33591, MSSA ATCC 29213, and MRSE MED 820 and ≥3-log10 kill against VISA HIP 5836, MSSE SU03, PSSP MED35, PSSP MED1119, and Streptococcus pyogenes MED 2040 strains.

Molecular Formula	C₈₇H₉₅Cl₃N₁₆O₂₈S₂
Molecular Weight	1983.26