dasabuvir sodium

Modify Date: 2024-01-05 15:36:20

dasabuvir sodium structure	Common Name	dasabuvir sodium
	CAS Number	1132940-11-4	Molecular Weight	515.55700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆N₃NaO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of dasabuvir sodium

Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively[1].

Name	dasabuvir sodium

Description	Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: 2.2 ± 0.3 nM (HCV genotype 1b N), 2.8 ± 0.2 nM (HCV genotype 1a H77), 3.1 ± 0.21 nM (HCV genotype 1b BK), 0.7 ± 1.4 nM (HCV genotype 1b Con1)[1]
In Vitro	Dasabuvir (ABT-333) sodium is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases[1]. Dasabuvir sodium inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM[1]. Dasabuvir sodium inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively[1].
References	[1]. Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.

Molecular Formula	C₂₆H₂₆N₃NaO₅S
Molecular Weight	515.55700
Exact Mass	515.14900
PSA	106.61000
LogP	5.69770

dasabuvir sodium

Use of dasabuvir sodium

Names

dasabuvir sodium Biological Activity

Chemical & Physical Properties