10.1016/j.stem.2017.05.016

2017-06-01

In an interview with Cell Stem Cell for our tenth anniversary, Drs. Fred Gage, Kristin Baldwin, and Hongkui Deng discuss exciting breakthroughs and remaining challenges in the fields of iPSC reprogramming, direct reprogramming, and in vivo reprogramming.

10.1016/j.stem.2017.05.017

2017-06-01

Think back to where you were and what you were doing 10 years ago. Maybe you were in graduate school, maybe even high school, or perhaps you had just started your first lab and were working out how to transition from being a postdoc to being a leader of a sci...

10.1016/j.stem.2017.05.018

2017-06-01

Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article in Nature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC po...

10.1016/j.stem.2017.04.002

2017-05-16

Inactivating mutations in the thyroid hormone (TH) transporterMonocarboxylate transporter 8(MCT8) cause severe psychomotor retardation in children. Animal models do not reflect the biology of the human disease. Using patient-specific induced pluripotent stem ...

10.1016/j.stem.2017.04.002

2017-05-16

Vatine et al. show that human iPSC-based modeling can pinpoint the origin of a neuronal disorder in the brain as a defect in transport of thyroid hormone across the blood-brain barrier, rather than in the neurons themselves.

10.1016/j.stem.2017.04.003

2017-05-11

A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis. Adult stem cells maintain and regenerate multiple mature cell lineages in t...

10.1016/j.stem.2017.03.024

2017-05-11

To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2...

10.1016/j.stem.2017.03.024

2017-05-11

Lechner et al. identify regenerative myeloid subpopulations, including recruited CCR2+ monocytes and Arginase1+ macrophages, during pneumonectomy-induced lung regeneration. Loss of recruited monocytes or Il4ra signaling impaired lung regeneration. The authors...

10.1016/j.stem.2017.04.003

2017-05-11

The olfactory epithelium is a site of active neurogenesis. Fletcher et al. combine single-cell transcriptomics and clonal lineage analysis to trace cell fates from the multipotent olfactory stem cell and identify multiple mechanisms controlling cell fate, inc...

10.1016/j.stem.2017.03.013

2017-05-04

Gupta and colleagues highlight recent work, including their own, that suggested based on lineage tracing that mural cells are adipogenic, contrasting with the conclusions of a recent Cell Stem Cell paper.