Cidofovir Dihydrate
Cidofovir Dihydrate structure
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Common Name | Cidofovir Dihydrate | ||
|---|---|---|---|---|
| CAS Number | 149394-66-1 | Molecular Weight | 315.22 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 609.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C8H18N3O8P | Melting Point | 260ºC (dec) | |
| MSDS | N/A | Flash Point | 322.4±34.3 °C | |
Use of Cidofovir DihydrateCidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.Target: CMV DNA polymeraseCidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Hol?, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | cidofovir dihydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.Target: CMV DNA polymeraseCidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Hol?, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 609.5±65.0 °C at 760 mmHg |
| Melting Point | 260ºC (dec) |
| Molecular Formula | C8H18N3O8P |
| Molecular Weight | 315.22 |
| Flash Point | 322.4±34.3 °C |
| PSA | 157.71000 |
| LogP | -3.37 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Index of Refraction | 1.656 |
| InChIKey | FPKARFMSZDBYQF-ILKKLZGPSA-N |
| SMILES | Nc1ccn(CC(CO)OCP(=O)(O)O)c(=O)n1.O.O |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Cidofovir hydrate (1:2) |
| Gs-0504 |
| Cidofovir dihydrate |
| ({[(2S)-1-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid |
| Cidofovir |
| (S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid |
| Unii-jil713Q00n |
| (S)-HPMPC Hydrate |
| Cidovir Hydrate |
| Vistide Hydrate |
| (S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl-1-(hydroxymethyl)ethoxy)methyl phosphonic acid |
| ({[(2S)-1-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-3-hydroxy-2-propanyl]oxy}methyl)phosphonic acid |
| Vistide |
| Drg-0145 |
| Cidofovir hydrate |
| GS 0504 Hydrate |
| Cidofovir (dihydrate) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of cidofovir dihydrate? |
| A: Molecular formula of cidofovir dihydrate is C8H18N3O8P. |
| Q: What is the melting point of cidofovir dihydrate? |
| A: Melting point of cidofovir dihydrate is 260ºC (dec). |
| Q: What is the English name of cidofovir dihydrate? |
| A: The English name of cidofovir dihydrate is cidofovir dihydrate. |
| Q: What is the InChIKey of cidofovir dihydrate? |
| A: InChIKey of cidofovir dihydrate is FPKARFMSZDBYQF-ILKKLZGPSA-N. |
| Q: What is the CAS number of cidofovir dihydrate? |
| A: CAS number of cidofovir dihydrate is 149394-66-1. |
| Q: What is the boiling point of cidofovir dihydrate? |
| A: Boiling point of cidofovir dihydrate is 609.5±65.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of cidofovir dihydrate? |
| A: Polar surface area (PSA) of cidofovir dihydrate is 157.71000. |
| Q: What is the LogP of cidofovir dihydrate? |
| A: LogP of cidofovir dihydrate is -3.37. |
| Q: What is the molecular weight of cidofovir dihydrate? |
| A: Molecular weight of cidofovir dihydrate is 315.22. |
| Q: What is the SMILES notation of cidofovir dihydrate? |
| A: SMILES notation of cidofovir dihydrate is Nc1ccn(CC(CO)OCP(=O)(O)O)c(=O)n1.O.O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |