Beta-d-N4-hydroxycytidine

Modify Date: 2026-07-01 06:27:47

Beta-d-N4-hydroxycytidine Structure
Beta-d-N4-hydroxycytidine structure
Common Name Beta-d-N4-hydroxycytidine
CAS Number 3258-02-4 Molecular Weight 259.21600
Density N/A Boiling Point N/A
Molecular Formula C9H13N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Beta-d-N4-hydroxycytidine


Beta-d-N4-hydroxycytidine is a very potent anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426, 1.036, and 2.5 μM, respectively[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
Synonym More Synonyms

 Beta-d-N4-hydroxycytidine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Beta-d-N4-hydroxycytidine is a very potent anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426, 1.036, and 2.5 μM, respectively[1].
Related Catalog
References

[1]. Urakova N, et al. β-d-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome. J Virol. 2018 Jan 17;92(3). pii: e01965-17.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula C9H13N3O6
Molecular Weight 259.21600
Exact Mass 259.08000
PSA 137.07000
InChIKey XCUAIINAJCDIPM-XVFCMESISA-N
SMILES O=c1nc(NO)ccn1C1OC(CO)C(O)C1O

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  0

DownStream  1

 Beta-d-N4-hydroxycytidineBioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antiviral activity against wild type SARS CoV-2 infected in Vero E6 cells transfected...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5112762
Name: Antiviral activity against wild type SARS CoV-2 infected in Vero E6 cells transfected...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5112763
Name: Cytotoxicity against African green monkey Vero E6 cells transfected with TMPRSS2 asse...
Source: ChEMBL
Target: Vero C1008
External Id: CHEMBL5112764
Name: Antiviral activity against SARS CoV infected in HEK293T cells transfected with ACE2 a...
Source: ChEMBL
Target: Severe acute respiratory syndrome-related coronavirus
External Id: CHEMBL5112765
Name: Antiviral activity against SARS CoV-2 delta TY11-927 infected in HEK293T cells transf...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5112758
Name: Half life in CD1 mouse at 150 mg/kg, po administered as single dose by LC-MS/MS analy...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5137627
Name: Antiviral activity against SARS CoV-2 omicron TY38-873 BA.1 variant infected in HEK29...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5112759
Name: Half life in CD1 mouse at 500 mg/kg, po administered as single dose by LC-MS/MS analy...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5137628
Name: Antiviral activity against SARS CoV-2 omicron TY38-873 BA.2 variant infected in HEK29...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5112760
Name: Substrate activity at human mARC1 expressed in Escherichia coli assessed as turnover ...
Source: ChEMBL
Target: Mitochondrial amidoxime-reducing component 1
External Id: CHEMBL4614164
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Uridine,4-oxime
N4-Hydroxycytidine
Cytidine,N-hydroxy
4-N-Hydroxycytidine
EIDD-1931

 Beta-d-N4-hydroxycytidine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the Chinese name of 3258-02-4?
A: Chinese name of 3258-02-4 is Beta-d-N4-hydroxycytidine.
Q: What English synonyms does 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one have?
A: English synonyms of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one: Uridine,4-oxime, N4-Hydroxycytidine, Cytidine,N-hydroxy, 4-N-Hydroxycytidine, EIDD-1931.
Q: What is the polar surface area (PSA) of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: Polar surface area (PSA) of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is 137.07000.
Q: What is the CAS number of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: CAS number of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is 3258-02-4.
Q: What is the molecular weight of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: Molecular weight of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is 259.21600.
Q: What is the InChIKey of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: InChIKey of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is XCUAIINAJCDIPM-XVFCMESISA-N.
Q: What is the molecular formula of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: Molecular formula of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is C9H13N3O6.
Q: What are the downstream products of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: Related downstream products(CAS) of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one: 65-46-3.
Q: What are the uses of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: Main uses of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one: Beta-d-N4-hydroxycytidine is a very potent anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426, 1.036, and 2.5 μM, respectively[1].
Q: What is the English name of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one?
A: The English name of 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one is 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one.

 Beta-d-N4-hydroxycytidinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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