6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID

Modify Date: 2026-06-30 19:07:15

6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID Structure
6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID structure
Common Name 6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID
CAS Number 327-20-8 Molecular Weight 229.155
Density 1.5±0.1 g/cm3 Boiling Point 402.5±40.0 °C at 760 mmHg
Molecular Formula C10H6F3NO2 Melting Point N/A
MSDS N/A Flash Point 197.2±27.3 °C

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 6-(trifluoromethyl)-1H-indole-2-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Boiling Point 402.5±40.0 °C at 760 mmHg
Molecular Formula C10H6F3NO2
Molecular Weight 229.155
Flash Point 197.2±27.3 °C
Exact Mass 229.035065
PSA 53.09000
LogP 2.88
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.598
InChIKey CDWGDLKZKCYUFO-UHFFFAOYSA-N
SMILES O=C(O)c1cc2ccc(C(F)(F)F)cc2[nH]1

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 6-(Trifluoromethyl)indole-2-carboxylic acid
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:6-(Trifluoromethyl)indole-2-carboxylic acid
CAS number:327-20-8

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C10H6F3NO2
Molecular weight:229.2

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code 2933990090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

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6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID Structure

6-TRIFLUOROMETH...

CAS#:327-20-8

Learn More
Literature: US2007/88071 A1, ; Page/Page column 16 ; US 20070088071 A1

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6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID Structure

6-TRIFLUOROMETH...

CAS#:327-20-8

Learn More
Literature: Journal of the American Chemical Society, , vol. 79, p. 1745,1747

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  2

DownStream  2

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

6-(Trifluoromethyl)-2-indole carboxylic acid
6-(Trifluoromethyl)-1H-indole-2-carboxylic acid
6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID
6-(Trifluoromethyl)indole-2-carboxylic acid
6-Trifluormethyl-indol-2-carbonsaeure
MFCD02664465

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Related upstream materials(CAS) of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid: 124-38-9;327-21-9.
Q: What is the molecular weight of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Molecular weight of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is 229.155.
Q: What is the polar surface area (PSA) of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Polar surface area (PSA) of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is 53.09000.
Q: What is the boiling point of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Boiling point of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is 402.5±40.0 °C at 760 mmHg.
Q: What is the CAS number of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: CAS number of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is 327-20-8.
Q: What is the SMILES notation of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: SMILES notation of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is O=C(O)c1cc2ccc(C(F)(F)F)cc2[nH]1.
Q: What is the English name of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: The English name of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is 6-(trifluoromethyl)-1H-indole-2-carboxylic acid.
Q: What are the downstream products of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Related downstream products(CAS) of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid: 103027-97-0;107516-75-6.
Q: What is the molecular formula of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid?
A: Molecular formula of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid is C10H6F3NO2.
Q: What English synonyms does 6-(trifluoromethyl)-1H-indole-2-carboxylic acid have?
A: English synonyms of 6-(trifluoromethyl)-1H-indole-2-carboxylic acid: 6-(Trifluoromethyl)-2-indole carboxylic acid, 6-(Trifluoromethyl)-1H-indole-2-carboxylic acid, 6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID, 6-(Trifluoromethyl)indole-2-carboxylic acid, 6-Trifluormethyl-indol-2-carbonsaeure, MFCD02664465.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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