Ombitasvir
Modify Date: 2025-08-25 16:25:20
Ombitasvir structure
|
Common Name | Ombitasvir | ||
|---|---|---|---|---|
| CAS Number | 1258226-87-7 | Molecular Weight | 894.109 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 1065.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C50H67N7O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 598.2±34.3 °C | |
Use of OmbitasvirOmbitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. |
| Name | ombitasvir |
|---|---|
| Synonym | More Synonyms |
| Description | Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.82 to 19.3 pM (HCV genotypes 1 to 5), 366 pM (HCV genotype 6a)[1] |
| In Vitro | Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively[1]. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 1065.6±65.0 °C at 760 mmHg |
| Molecular Formula | C50H67N7O8 |
| Molecular Weight | 894.109 |
| Flash Point | 598.2±34.3 °C |
| Exact Mass | 893.505127 |
| PSA | 178.72000 |
| LogP | 6.29 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | -20℃ |
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| ABT-267 |
| Ombitasvir |
| UNII:2302768XJ8 |
| Dimethyl ({(2S,5S)-1-[4-(2-methyl-2-propanyl)phenyl]-2,5-pyrrolidinediyl}bis{4,1-phenylenecarbamoyl(2S)-2,1-pyrrolidinediyl[(2S)-3-methyl-1-oxo-1,2-butanediyl]})biscarbamate |