Protocatechuic acid methyl ester

Modify Date: 2025-08-23 19:58:35

Protocatechuic acid methyl ester structure	Common Name	Protocatechuic acid methyl ester
	CAS Number	2150-43-8	Molecular Weight	168.147
	Density	1.4±0.1 g/cm3	Boiling Point	351.5±22.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₄	Melting Point	134-135°C
	MSDS	N/A	Flash Point	148.5±15.8 °C

Use of Protocatechuic acid methyl ester

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1].

Name	Methyl 3,4-dihydroxybenzoate
Synonym	More Synonyms

Description	Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cancer Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology
In Vitro	Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) alleviates the toxic effects of F- via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells[1].
In Vivo	Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) (25 or 50 mg/kg bw/day) prevents the cellular F- accumulation and oxidative stress. It prevents the inflammatory and associated fibrosis progression by restoring the expression of RAGE and Nrf2[2].
References	[1]. Ameeramja J, et al. Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):941-950. [2]. Ameeramja J, et al. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018 Aug;118:235-244.

Density	1.4±0.1 g/cm3
Boiling Point	351.5±22.0 °C at 760 mmHg
Melting Point	134-135°C
Molecular Formula	C₈H₈O₄
Molecular Weight	168.147
Flash Point	148.5±15.8 °C
Exact Mass	168.042252
PSA	66.76000
LogP	1.69
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.588

Protocatechuic acid methyl ester MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
HS Code	2918290000

Precursor 10
CAS#:67-56-1 Methanol CAS#:99-50-3 protocatechuic acid CAS#:149-73-5 Trimethyl ortho... CAS#:3943-74-6 Methyl vanillate
CAS#:99-76-3 Methyl 4-hydrox... CAS#:484018-34-0 methyl 4-(cyclo... CAS#:74997-71-0 lithium 4-(meth... CAS#:326-56-7 Methyl piperonylate
CAS#:5026-62-0 Methylparaben S... CAS#:1000180-42-6 2-(3,4-dihydrox...
DownStream 10
CAS#:476168-17-9 Methyl 2-amino-... CAS#:94-53-1 Heliotropic acid CAS#:3693-53-6 Carbamic acid,N... CAS#:4143-64-0 3',4'-Dihydroxy...
CAS#:491-70-3 Luteolin CAS#:39635-11-5 3,4-dihydroxybe... CAS#:180678-33-5 3,4-dihexadecox... CAS#:180678-39-1 4-(3,4-didecoxy...
CAS#:180678-30-2 methyl 3,4-dihe... CAS#:179688-14-3 methyl 3,4-bis(...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3,4-DIHYDROXY-BENZOIC ACID METHYL ESTER

3,4-dihydroxy methyl benzoate

MFCD00016437

3,4-Dihydroxybenzoic Acid Methyl Ester

Protocatechuic acid,methyl ester

3,4-dihydroxy-6-methoxycarbonylbenzene

Methyl 3,4-dihydroxybenzoate

Protocatechuic Acid Methyl Ester

Benzoic acid, 3,4-dihydroxy-, methyl ester

Methyl Protocatechuate

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Protocatechuic acid methyl ester
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Protocatechuic acid methyl ester
Price: ￥348.0/25g ￥118.0/5g ￥198.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Methyl 3,4-dihydroxybenzoate
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Methyl 3,4-dihydroxybenzoate
Price: $80.0/100mg $160.0/250mg $320.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methyl 3,4-dihydroxybenzoate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Protocatechuic acid methyl ester

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