Ceftarolin Fosamil
Published date: 2022-03-23 10:26:48
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Name | Ceftarolin Fosamil | CAS# | 866021-48-9 |
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| Price | $Inquiry/1kg | Purity | 99.0% | |
| Stocking Period |
Inquiry | Stock | In Stock |
| Detail
Product Information
Name: Ceftarolin Fosamil CAS: 866021-48-9 Synonyms: Ceftaroline Unii-p9vxv1408y Ceftarolin Fosamil Ceftaroline Impurity8 Ceftaroline USP/EP/BP Unii-p9vxv1408y USP/EP/BP Ceftaroline Fosamil Acetate Hydrate 7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1 acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino) Antimicrobial activity: A semisynthetic cephalosporin formulated as the water-soluble fosamil acetate prodrug for intravenous administration. Its properties are similar to those of ceftobiprole, with which it shares an enhanced affinity for penicillin-binding protein 2′ (2a) of methicillin-resistant Staph. aureus. It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative bacilli. Pharmacokinetics: Cmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion Plasma half-life: 2.6 h Volume of distribution: 0.37 L/kg Plasma protein binding :<20% Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in plasma after intravenous infusion and excreted principally in urine. In preliminary clinical studies it appears to be well tolerated.
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