Tetrahedron Letters

An atom-economic and odorless thia-Michael addition in a deep eutectic solvent

N Azizi, Z Yadollahy, A Rahimzadeh-Oskooee

Index: Azizi, Najmedin; Yadollahy, Zahra; Rahimzadeh-Oskooee, Amin Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1722 - 1725

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Citation Number: 14

Abstract

Abstract The first 100% atom-efficient and odorless protocol for carbon–sulfur bond formation in a deep eutectic solvent (DES) as both the reaction medium and catalyst is reported. The biodegradable and inexpensive DES provides an efficient and convenient ionic reaction medium for the thia-Michael addition with in situ generation of S- alkylisothiouronium salts in place of thiols without the urea by-product segment. This ...