Synthesis of new cotelomers derived from tris (hydroxymethyl) aminomethane bearing arabinofuranosylcytosine moieties. Preliminary results on their in vitro and in …

…, JC Maurizis, M Ollier, M Rapp, JM Lacombe…

Index: Contino, Christiane; Maurizis, Jean-Claude; Ollier, Monique; Rapp, Maryse; Lacombe, Jean-Michel; Pucci, Bernard European Journal of Medicinal Chemistry, 1998 , vol. 33, # 10 p. 809 - 816

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Citation Number: 11

Abstract

As an approach to the development of drug delivery systems, a new class of low macromolecular carriers called telomers bearing both antitumor agent such as arabinofuranosylcytosine (Ara-C) and galactose moieties were synthesized. These compounds were prepared by telomerization of tris (hydroxymethyl) acrylamidomethane (THAM) or monogalactosylated THAM and Ara-C polymerizable derivatives in the ...