Bioorganic & medicinal chemistry letters

Exploration of secondary and tertiary pharmacophores in unsymmetrical N, N′-diaryl urea inhibitors of soluble epoxide hydrolase

SK Anandan, RD Gless

Index: Anandan, Sampath-Kumar; Gless, Richard D. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2740 - 2744

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Citation Number: 19

Abstract

The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N, N′-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.