Synthesis of amino acids and related compounds. 4. New synthesis of. alpha.-amino acids

K Matsumoto, M Suzuki, M Miyoshi

Index: Matsumoto,K. et al. Journal of Organic Chemistry, 1973 , vol. 38, p. 2094 - 2096

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Citation Number: 27

Abstract

When the various isocyanides (3) reacted with diethyl carbonate in the presence of sodium hydride in dimethylformamide, ethoxycarbonylation proceeded easily at the a carbon of the isocyanides, and the corresponding ethyl a-isocyanoacetat, e derivatives (5, R'= Et) were obtained in 59-63% yields as listed in Table The ir spectra of these compounds