Antimalarials. 13. 5-Alkoxy analogs of 4-methylprimaquine

MP LaMontagne, A Markovac…

Index: LaMontage, Maurice P.; Markovac, Anica; Khan, M. Sami Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 964 - 968

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Citation Number: 40

Abstract

3 amino-5-nitro-l, 2-(methylenedioxy) benzene were prepared by Lott et al. 6 Treatment of the appropriately substituted o-nitroaniline with the appropriate a, P-unsaturated aldehyde or ketone afforded the requisite 5, 6-disubstituted 8-nitroquinolines 1. Reduction with commercially available wet Raney nickel yielded the substituted &aminoquinolines 2. Condensation with the appropriate haloalkylphthalimides afforded the protected B- ...