Novel 6-oxo-6-naphthylhexanoic acid derivatives with anti-inflammatory and 5-lipoxygenase inhibitory activity

…, MP Wachter, AM Kasper, DC Argentieri…

Index: Murray, W.V.; Wachter, M.P.; Kasper, A.M.; Argentieri, D.C.; Capetola, R.J.; Ritchie, D.M. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 159 - 166

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Citation Number: 12

Abstract

Abstract A series of novel 6-(6-alkoxy-2-naphthyl) oxoalkanoates and alkanamides were synthesized as inhibitors of inflammation and 5-lipoxygenase. They were evaluated in vivo for anti-inflammatory activity in the established adjuvent arthritis assay in rats and in vitro as inhibitors of 5-lipoxygenase in rat basophilic leukemia (RBL) cells. N-Hydroxy-N-methyl-6-(6- methoxy-2-naphthyl)-6-oxohexanamide, compound 28, which is representative of the ...