Direct Dehydrogenative Amide Synthesis from Alcohols and Amines Catalyzed by γ??Alumina Supported Silver Cluster

…, K Ohshima, A Satsuma

Index: Shimizu, Ken-Ichi; Ohshima, Keiichiro; Satsuma, Atsushi Chemistry - A European Journal, 2009 , vol. 15, # 39 p. 9977 - 9980

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Citation Number: 124

Abstract

Aromatic and aliphatic amides are functional groups of great importance in polymers, natural products, and pharmaceuticals.[1] Synthesis of amides is mostly based on activated acid derivatives (acid chlorides and anhydrides) or rearrangement reactions induced by an acid or base.[2] Alternative procedures include the Staudinger ligation,[3a] aminocarbonylation of aryl halides,[3b] oxidative amidation of aldehydes,[3c–f] and amidation of alcohols with ...