Metal-free, hydroacylation of C [double bond, length as m-dash] C and N [double bond, length as m-dash] N bonds via aerobic C–H activation of aldehydes, …

V Chudasama, AR Akhbar, KA Bahou…

Index: Chudasama, Vijay; Akhbar, Ahmed R.; Bahou, Karim A.; Fitzmaurice, Richard J.; Caddick, Stephen Organic and Biomolecular Chemistry, 2013 , vol. 11, # 42 p. 7301 - 7317

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Abstract

In this report, a thorough evaluation of the use of aerobically initiated, metal-free hydroacylation of various CC and NN acceptor molecules with a wide range of aldehydes is presented. The aerobic-activation conditions that have been developed are in sharp contrast to previous conditions for hydroacylation, which tend to use transition metals, peroxides that require thermal or photochemical degradation, or N-heterocyclic carbenes. The mildness ...