European journal of medicinal chemistry

Functionalized aurones as inducers of NAD (P) H: quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR

CY Lee, EH Chew, ML Go

Index: Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971

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Citation Number: 42

Abstract

The chemopreventive potential of functionalized aurones and related compounds as inducers of NAD (P) H: quinone oxidoreductase 1 (NQO1, EC 1.6. 99.2) are described. Several 4, 6-dimethoxy and 5-hydroxyaurones induced NQO1 activity of Hepa1c1c7 cells by 2-fold at submicromolar concentrations, making these the most potent inducers to be identified from this class. Mechanistically, induction of NQO1 was mediated by the ...