Cerium metal-mediated Reformatsky-type reaction with ethyl bromosuccinate for the synthesis of novel paraconic acid analogs

SMM Rodrigues, V Nardini, MG Constantino…

Index: Rodrigues, Shirley M. M.; Nardini, Viviani; Constantino, Mauricio G.; Da Silva, Gil Valdo J. Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6136 - 6137,2

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Citation Number: 4

Abstract

The treatment of cerium metal with ethyl bromosuccinate (1) forms the stabilized organolanthanoid intermediate (2), which reacts with carbonyl compounds in a Reformatsky- type reaction, under mild conditions, to produce functionalized γ-substituted paraconic acids (4) in good yields.