A number of 2′-and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′- halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.
