Il Farmaco 2002-08-01

Synthesis and antimicrobial activity of new adamantane derivatives III.

Andrzej Orzeszko, Beata Kamińska, Bohdan J Starościak

Index: Il Farmaco 57(8) , 619-24, (2002)

Full Text: HTML

Abstract

Some novel ester imides synthesised from trimellitic acid anhydride and 1-adamantanol or 2-adamantanol, were tested as antimicrobial compounds. Unfortunately, these agents showed a modest antibacterial activity (MIC > 6 microg/ml). However, a comparison of these N-substituted adamantylester imides with the series published previously, indicated that the incorporation of L-alanine and L-phenylalanine into the phthalimide moiety was the best choice regardless of the series and leads to antimicrobial activity against Staphylococcus aureus strains.