Journal of the American Chemical Society 2006-01-18

Titanium(II)-mediated cyclizations of (silyloxy)enynes: a total synthesis of (-)-7-demethylpiericidin A1.

Katie A Keaton, Andrew J Phillips

Index: J. Am. Chem. Soc. 128(2) , 408-9, (2006)

Full Text: HTML

Abstract

A concise total synthesis of 7-demethylpiericidin A1 has been completed. The synthesis features a titanium(II)-mediated cyclization of a (silyloxy)enyne as the key step and proceeds in nine steps from tiglic aldehyde.