Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiiskaia akademiia nauk 2010-01-01

[Wound healing potential of chitosan and its N-sulfosuccinoyl derivatives].

T P Alekseeva, A A Rakhmetova, O A Bogoslovskaia, I P Ol'khovskaia, A N Levov, A V Il'ina, V P Varlamov, T A Baĭtukalov, N N Glushchenko

Index: Izv. Akad. Nauk Ser. Biol. (4) , 403-10, (2010)

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Abstract

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.