The Journal of Organic Chemistry

Total synthesis of nitidine chloride

M Cushman, L Cheng

Index: Cushman,M.; Cheng,L. Journal of Organic Chemistry, 1978 , vol. 43, p. 286 - 288

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Citation Number: 99

Abstract

Anal. Calcd foi C~ JH~~ NO;: C, 62.33; H, 4.97; N, 3.63. Found: C, 62.23; H, 5.12; N, 3.80. trans-N-Methyl-3-(~ l', 4'-methylenedioxyphenyl)-4-carboxy-6, 7-dimethoxy-3, 4-dihydro-1 (2H)-isoquinolone (5). The filtrate from the previous experiment was concentrated and the residue recrystallized from ethyl acetate to give a colorless solid (1.52 g, 39%): mp 208-209" C; IF1 (KBr) 3400-2400, 1735, 1625, 1605 cm-'; NMR (MesSO-dsi 6 13.00 (br s, 1 H, ...