Synthesis and antitumor activity of some 8-substituted-4-oxo-4H-1-benzopyrans

G Atassi, P Briet, JJ Berthelon, F Collonges

Index: Atassi; Briet; Berthelon; Collonges European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 393 - 402

Full Text: HTML

Citation Number: 124

Abstract

... Titre du document / Document title. Synthesis and antitumor activity of some 8-substituted-4-oxo- 4H-1-benzopyrans. Auteur(s) / Author(s). ATASSI G. ; BRIET P. ; BERTHELON J.-J. ; COLLONGES F. ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). Inst. Jules Bordet Revue / Journal Title. European journal of medicinal chemistry ISSN 0223-5234 CODEN EJMCA5 Source / Source. 1985, vol. 20, n o 5, pp. 393-402 (24 ref.) Langue / Language. Anglais ...

 Related Synthetic Route
mitoflaxone Structure

87626-55-9

mitoflaxone

Ethylene glycol Structure

107-21-1

Ethylene glycol

~70%

4H-1-Benzopyran-8-aceticacid, 4-oxo-2-phenyl-, 2-hydroxyethyl ester Structure

87626-65-1

4H-1-Benzopyran...

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

4H-1-Benzopyran-8-aceticacid, 4-oxo-2-phenyl-, 2-hydroxyethyl ester Structure

87626-65-1

4H-1-Benzopyran...

4-oxo-2-phenyl-4H-1-benzopyran-8-acetonitrile Structure

87626-54-8

4-oxo-2-phenyl-...

~%

4H-1-Benzopyran-8-aceticacid, 4-oxo-2-phenyl-, 2-hydroxyethyl ester Structure

87626-65-1

4H-1-Benzopyran...

2-(6-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)acetonitrile Structure

87626-73-1

2-(6-methyl-4-o...

~54%

6-methylflavone-8-acetic acid Structure

87626-74-2

6-methylflavone...

8-(bromomethyl)-2,3-diphenyl-4H-chromen-4-one Structure

87165-76-2

8-(bromomethyl)...

~%

2-(4-oxo-2,3-diphenyl-chromen-8-yl)acetic acid Structure

87627-20-1

2-(4-oxo-2,3-di...

2-(4-oxo-2,3-diphenyl-4H-chromen-8-yl)acetonitrile Structure

87627-19-8

2-(4-oxo-2,3-di...

~31%

2-(4-oxo-2,3-diphenyl-chromen-8-yl)acetic acid Structure

87627-20-1

2-(4-oxo-2,3-di...

POTASSIUM CYANIDE Structure

151-50-8

POTASSIUM CYANIDE

8-(bromomethyl)-2-methylchromen-4-one Structure

87165-87-5

8-(bromomethyl)...

~73%

2-(2-methyl-4-oxochromen-8-yl)acetonitrile Structure

87627-21-2

2-(2-methyl-4-o...

4-oxo-2-phenyl-4H-1-benzopyran-8-acetonitrile Structure

87626-54-8

4-oxo-2-phenyl-...

~86%

mitoflaxone Structure

87626-55-9

mitoflaxone

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

mitoflaxone Structure

87626-55-9

mitoflaxone

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

N-(2-diethylaminoethyl)-2-(4-oxo-2-phenyl-chromen-8-yl)acetamide Structure

87626-66-2

N-(2-diethylami...

ethyl 4-oxo-2-phenyl-4H-1-benzopyran-8-acetate Structure

87626-62-8

ethyl 4-oxo-2-p...

2-aminoethyldiethylamine Structure

100-36-7

2-aminoethyldie...

~40%

N-(2-diethylaminoethyl)-2-(4-oxo-2-phenyl-chromen-8-yl)acetamide Structure

87626-66-2

N-(2-diethylami...

mitoflaxone Structure

87626-55-9

mitoflaxone

~%

N-(2-diethylaminoethyl)-2-(4-oxo-2-phenyl-chromen-8-yl)acetamide Structure

87626-66-2

N-(2-diethylami...

4-oxo-2-phenyl-4H-1-benzopyran-8-acetonitrile Structure

87626-54-8

4-oxo-2-phenyl-...

~%

N-(2-diethylaminoethyl)-2-(4-oxo-2-phenyl-chromen-8-yl)acetamide Structure

87626-66-2

N-(2-diethylami...

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

3-dimethylaminopropyl 2-(4-oxo-2-phenyl-chromen-8-yl)acetate Structure

87626-60-6

3-dimethylamino...

4-oxo-2-phenyl-4H-1-benzopyran-8-acetonitrile Structure

87626-54-8

4-oxo-2-phenyl-...

~%

3-dimethylaminopropyl 2-(4-oxo-2-phenyl-chromen-8-yl)acetate Structure

87626-60-6

3-dimethylamino...

mitoflaxone Structure

87626-55-9

mitoflaxone

3-Chloro-N,N-dimethylpropan-1-amine Structure

109-54-6

3-Chloro-N,N-di...

~%

3-dimethylaminopropyl 2-(4-oxo-2-phenyl-chromen-8-yl)acetate Structure

87626-60-6

3-dimethylamino...

2-(2-(4-methoxyphenyl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87627-09-6

2-(2-(4-methoxy...

~87%

2-[2-(4-methoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87627-10-9

2-[2-(4-methoxy...

8-(bromomethyl)-2-(4-methoxyphenyl)chromen-4-one Structure

87165-56-8

8-(bromomethyl)...

~%

2-[2-(4-methoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87627-10-9

2-[2-(4-methoxy...

8-(bromomethyl)-2-(3-methoxyphenyl)chromen-4-one Structure

87165-66-0

8-(bromomethyl)...

~%

2-[2-(3-methoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87626-92-4

2-[2-(3-methoxy...

2-(2-(3-methoxyphenyl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87626-91-3

2-(2-(3-methoxy...

~21%

2-[2-(3-methoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87626-92-4

2-[2-(3-methoxy...

2-(2-benzyl-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87627-14-3

2-(2-benzyl-4-o...

~35%

4H-1-Benzopyran-8-aceticacid, 4-oxo-2-(phenylmethyl)- Structure

87627-18-7

4H-1-Benzopyran...

2-benzyl-8-(bromomethyl)-4H-chromen-4-one Structure

87165-89-7

2-benzyl-8-(bro...

~%

4H-1-Benzopyran-8-aceticacid, 4-oxo-2-(phenylmethyl)- Structure

87627-18-7

4H-1-Benzopyran...

2-(2-(furan-2-yl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87627-01-8

2-(2-(furan-2-y...

~49%

4H-1-Benzopyran-8-acetic acid, 2-(2-furanyl)-4-oxo- Structure

87627-02-9

4H-1-Benzopyran...

8-(bromomethyl)-2-(furan-2-yl)-4H-chromen-4-one Structure

87165-78-4

8-(bromomethyl)...

~%

4H-1-Benzopyran-8-acetic acid, 2-(2-furanyl)-4-oxo- Structure

87627-02-9

4H-1-Benzopyran...

8-(bromomethyl)-2-cyclohexyl-4H-chromen-4-one Structure

87165-80-8

8-(bromomethyl)...

~%

2-(2-cyclohexyl-4-oxo-chromen-8-yl)acetic acid Structure

87627-16-5

2-(2-cyclohexyl...

2-(2-cyclohexyl-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87627-13-2

2-(2-cyclohexyl...

~24%

2-(2-cyclohexyl-4-oxo-chromen-8-yl)acetic acid Structure

87627-16-5

2-(2-cyclohexyl...

8-bromomethyl-3-phenyl-4H-1-benzopyran-4-one Structure

87165-82-0

8-bromomethyl-3...

~%

(4-Oxo-3-phenyl-4H-chromen-8-yl)acetic acid Structure

87627-17-6

(4-Oxo-3-phenyl...

TETRAETHYL DIMETHYLAMINOMETHYLENEDIPHOSPHONATE Structure

18855-52-2

TETRAETHYL DIME...

4-oxo-3-phenyl-4H-1-benzopyran-8-carboxaldehyde Structure

87627-15-4

4-oxo-3-phenyl-...

~%

(4-Oxo-3-phenyl-4H-chromen-8-yl)acetic acid Structure

87627-17-6

(4-Oxo-3-phenyl...

8-(bromomethyl)-2-methylchromen-4-one Structure

87165-87-5

8-(bromomethyl)...

~%

2-(2-methyl-4-oxo-chromen-8-yl)acetic acid Structure

87627-22-3

2-(2-methyl-4-o...

diethyl 2-((4-oxo-2-phenyl-4H-1-benzopyran-8-yl)methyl)propanedioate Structure

87626-99-1

diethyl 2-((4-o...

~51%

3-(4-oxo-2-phenyl-chromen-8-yl)propanoic acid Structure

87627-00-7

3-(4-oxo-2-phen...

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

3-(4-oxo-2-phenyl-chromen-8-yl)propanoic acid Structure

87627-00-7

3-(4-oxo-2-phen...

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-, 2-(diethylamino)ethyl ester,hydrochloride Structure

87626-57-1

4H-1-Benzopyran...

4-oxo-2-phenyl-4H-1-benzopyran-8-acetonitrile Structure

87626-54-8

4-oxo-2-phenyl-...

~%

4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-, 2-(diethylamino)ethyl ester,hydrochloride Structure

87626-57-1

4H-1-Benzopyran...

mitoflaxone Structure

87626-55-9

mitoflaxone

2-Chloro-N,N-diethylethanamine Structure

100-35-6

2-Chloro-N,N-di...

~%

4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-, 2-(diethylamino)ethyl ester,hydrochloride Structure

87626-57-1

4H-1-Benzopyran...

Methanol Structure

67-56-1

Methanol

2-(4-oxo-2-(thiophen-2-yl)-4H-chromen-8-yl)acetic acid Structure

87626-69-5

2-(4-oxo-2-(thi...

~70%

methyl 2-(4-oxo-2-thiophen-2-yl-chromen-8-yl)acetate Structure

87626-70-8

methyl 2-(4-oxo...

8-(bromomethyl)-2-(thiophen-2-yl)-4H-chromen-4-one Structure

87165-65-9

8-(bromomethyl)...

~%

methyl 2-(4-oxo-2-thiophen-2-yl-chromen-8-yl)acetate Structure

87626-70-8

methyl 2-(4-oxo...

2-(4-oxo-2-(thiophen-2-yl)-4H-chromen-8-yl)acetonitrile Structure

87626-68-4

2-(4-oxo-2-(thi...

~%

methyl 2-(4-oxo-2-thiophen-2-yl-chromen-8-yl)acetate Structure

87626-70-8

methyl 2-(4-oxo...

2-(4-oxo-2-(p-tolyl)-4H-chromen-8-yl)acetonitrile Structure

87627-03-0

2-(4-oxo-2-(p-t...

~60%

4H-1-Benzopyran-8-acetic acid, 2-(4-methylphenyl)-4-oxo- Structure

87627-04-1

4H-1-Benzopyran...

8-(bromomethyl)-2-(p-tolyl)-4H-chromen-4-one Structure

87165-55-7

8-(bromomethyl)...

~%

4H-1-Benzopyran-8-acetic acid, 2-(4-methylphenyl)-4-oxo- Structure

87627-04-1

4H-1-Benzopyran...

4-oxo-2-phenyl-4H-1-benzopyran-8-carboxaldehyde Structure

87626-84-4

4-oxo-2-phenyl-...

~%

2-Propenoicacid, 3-(4-oxo-2-phenyl-4H-1-benzopyran-8-yl)-, 2-(diethylamino)ethyl ester Structure

87626-87-7

2-Propenoicacid...

8-bromomethyl-2-phenyl-4H-1-benzopyran-4-one Structure

87165-52-4

8-bromomethyl-2...

~%

2-Propenoicacid, 3-(4-oxo-2-phenyl-4H-1-benzopyran-8-yl)-, 2-(diethylamino)ethyl ester Structure

87626-87-7

2-Propenoicacid...

3-(4-oxo-2-phenyl-4H-1-benzopyran.8.yl)-2-propenoic acid Structure

87626-86-6

3-(4-oxo-2-phen...

2-Chloro-N,N-diethylethanamine Structure

100-35-6

2-Chloro-N,N-di...

~%

2-Propenoicacid, 3-(4-oxo-2-phenyl-4H-1-benzopyran-8-yl)-, 2-(diethylamino)ethyl ester Structure

87626-87-7

2-Propenoicacid...

2-(2-(naphthalen-2-yl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87627-07-4

2-(2-(naphthale...

~62%

2-(2-naphthalen-2-yl-4-oxo-chromen-8-yl)acetic acid Structure

87627-08-5

2-(2-naphthalen...

8-(bromomethyl)-2-(naphthalen-2-yl)-4H-chromen-4-one Structure

87165-77-3

8-(bromomethyl)...

~%

2-(2-naphthalen-2-yl-4-oxo-chromen-8-yl)acetic acid Structure

87627-08-5

2-(2-naphthalen...

2-(2-(4-chlorophenyl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

101002-45-3

2-(2-(4-chlorop...

~55%

2-[2-(4-chlorophenyl)-4-oxochromen-8-yl]acetic acid Structure

101002-46-4

2-[2-(4-chlorop...

8-(bromomethyl)-2-(4-chlorophenyl)-4H-chromen-4-one Structure

87165-57-9

8-(bromomethyl)...

~%

2-[2-(4-chlorophenyl)-4-oxochromen-8-yl]acetic acid Structure

101002-46-4

2-[2-(4-chlorop...

2-(2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-8-yl)acetonitrile Structure

87626-97-9

2-(2-(3,4-dimet...

~35%

2-[2-(3,4-dimethoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87626-98-0

2-[2-(3,4-dimet...

8-(bromomethyl)-2-(3,4-dimethoxyphenyl)-4H-chromen-4-one Structure

87165-74-0

8-(bromomethyl)...

~%

2-[2-(3,4-dimethoxyphenyl)-4-oxo-chromen-8-yl]acetic acid Structure

87626-98-0

2-[2-(3,4-dimet...


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