… and biological evaluation of certain 2'-deoxy-. beta.-D-ribo-and 2. beta.-D-arabinofuranosyl nucleosides of purine-6-carboxamide and 4, 8-diaminopyrimido [5, 4-d] …

PC Srivastava, GR Revankar, RK Robins…

Index: Srivastava; Revankar; Robins; Rousseau Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 393 - 398

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Citation Number: 15

Abstract

394 Journal of Medicinal Chemistry, 1981, Vol. 24, No. 4 certain naturally ocurring purine nucleosides was recently considered. The nucleoside 6-amino-9-P-~- arabinofuranosylpurine (ara-A) is a clinically effective drug against herpes simplex virus infecti0ns. l A major disadvantage of this nucleoside is its relative insolubility in water which makes its intravenous administration difficult. 2 The 5'-phosphate of ara-A tends to ...