Biochemical and Biophysical Research Communications 1984-02-14

Formation of N-nitrosodiphenylamine from 1,1-diphenylhydrazine by rat liver microsomal preparations.

K Tatsumi, S Kitamura, M Sumida

Index: Biochem. Biophys. Res. Commun. 118(3) , 958-63, (1984)

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Abstract

The present study provides the first evidence for in vitro metabolic conversion of a 1,1-disubstituted hydrazine to the corresponding nitrosamine. The study shows that superoxide radical which is generated by NADPH-cytochrome c reductase is involved in the oxidation of 1,1-diphenylhydrazine to N-nitrosodiphenylamine catalyzed by rat liver microsomes.