Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 1992-11-01

The effects of m-octopamine on salivary flow rates and protein secretion by rat submandibular glands.

A Okina, K Abe, H Inuzuka, T Yano, T Okina, T Nakashima, T Nishiura

Index: Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. 103(3) , 469-76, (1992)

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Abstract

1. m-Octopamine given i.v. or i.p. was a potent sialogogue for rat salivary glands. 2. Salivation in response to i.v. m-octopamine was completely abolished by prazosin and phenoxybenzamine. 3. The alpha-type of proteins were secreted in response to all doses of i.v. and i.p. m-octopamine and these were converted into the beta-type with prazosin, but not with yohimbine. 4. m-Octopamine stimulated both alpha- and beta-adrenoceptors and was a much more selective alpha 1-agonist than was the p-isomer.