Organic Letters 2001-07-12

Total synthesis of epothilones B and D.

R E Taylor, Y Chen

Index: Org. Lett. 3(14) , 2221-4, (2001)

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Abstract

[reaction: see text] A highly convergent total synthesis of the natural products epothilone B and D is described. The route is highlighted by efficient generation of a C12-C13 trisubstituted olefin which exploits a sequential Nozaki-Hiyama-Kishi coupling and a stereoselective thionyl chloride rearrangement.