A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an iridium catalyst

M Chang, W Li, X Zhang

Index: Chang, Mingxin; Li, Wei; Zhang, Xumu Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10679 - 10681

Full Text: HTML

Citation Number: 62

Abstract

During the past two decades, a number of catalytic systems for asymmetric hydrogenation [5] and asymmetric transfer hydrogenation [6] of this class of imines have been invented. Using the chiral titanocene developed by Buchwald and Willoughby, 1-methyl-3, 4-dihydro-6, 7- dimethoxyisoquinoline was hydrogenated with 98% ee.[5a] Noyori and coworkers initiated research into the RuII/TsDPEN complex for the highly enantioselective transfer ...