Organic Letters 2010-04-02

Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones.

Yanchuan Zhao, Weizhou Huang, Lingui Zhu, Jinbo Hu

Index: Org. Lett. 12 , 1444-1447, (2010)

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Abstract

Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was found that the fluorinated sulfinate intermediate in the reaction is relatively stable, which can be observed by (19)F NMR and trapped with CH(3)I.