The Journal of organic chemistry

Multicomponent, One-Pot Sequential Synthesis of 1, 3, 5-and 1, 3, 5, 5-Substituted Barbiturates†

A Volonterio, M Zanda

Index: Volonterio, Alessandro; Zanda, Matteo Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7486 - 7497

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Citation Number: 31

Abstract

Carbodiimides and malonic acid monoethylesters readily react to afford N-acylurea derivatives that could be cyclized in situ by addition of a suitable base. This process represents a general and straightforward one-pot sequential synthesis of 1, 3, 5- trisubstituted barbiturates in very mild conditions (organic solvent/2 N NaOH aqueous solution, 20° C). Performing the reaction in the presence of an electrophile resulted in the ...