Steroids 1989-09-01

A convenient preparation of the side-chain lactone ring of a withanolide precursor.

A M Maione, A Romeo, C G Casinovi

Index: Steroids 54(3) , 313-20, (1989)

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Abstract

Condensation of C22 and C21 steroidal aldehydes with ethyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 1 in alkaline medium, followed by decarboxylation, provides a simple route to the alpha, beta-unsaturated side-chain delta-lactone synthesis for a classical withanolide precursor.