Bioscience, Biotechnology, and Biochemistry 2006-09-01

Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats.

Mitsuru Tanaka, Toshiro Matsui, Yusuke Ushida, Kiyoshi Matsumoto

Index: Biosci. Biotechnol. Biochem. 70 , 2292-2295, (2006)

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Abstract

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.