Bioorganic & Medicinal Chemistry Letters 1999-11-01

Convenient synthesis of L-proline benzyl ester.

A Córdova, N N Reed, J A Ashley, K D Janda

Index: Bioorg. Med. Chem. Lett. 9(21) , 3119-22, (1999)

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Abstract

Mesylates or tosylates of delta-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters.