Organic Letters 2007-06-21

Development of a catalytic aromatic decarboxylation reaction.

Joshua S Dickstein, Carol A Mulrooney, Erin M O'Brien, Barbara J Morgan, Marisa C Kozlowski

Index: Org. Lett. 9 , 2441, (2007)

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Abstract

A palladium-catalyzed aromatic decarboxylation reaction has been developed. With electron-rich aromatic acids, the reaction proceeds efficiently under fairly mild conditions in good yields. The method was useful with complex functionalized substrates containing hindered carboxylic acids.