Organic Letters 2001-07-12

First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist.

D Ma, C Xia, J Jiang, J Zhang

Index: Org. Lett. 3(14) , 2189-91, (2001)

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Abstract

[reaction: see text] The first total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist, via a CuI-catalyzed coupling reaction of beta-amino ester 6 with 1,4-diiodobenzene and a guanylation reaction of secondary amine 3 under mild conditions as key steps, is described.