Bioorganic & medicinal chemistry letters

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

B Jiang, XN Xiong, CG Yang

Index: Jiang, Biao; Xiong, Xen-Nan; Yang, Cai-Guang Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 475 - 477

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Citation Number: 29

Abstract

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4- trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2, 6-bis [3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.